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Subjects with end-stage renal disease (ESRD; CL CR=8.1±9.1mL/min) and who received a single intravenous infusion of metronidazole 500 mg had no significant change in metronidazole pharmacokinetics but had 2-fold higher Cmax of hydroxy-metronidazole and 5-fold higher Cmax of metronidazole acetate, compared to healthy subjects with normal renal function (CL CR=126±16 mL/min). I am just sad and depressed, and this doesn't help. Combination therapy has been associated with an increased risk of diarrhea, hypotension, syncope, hyperkalemia, and renal dysfunction resulting in dialysis, doubling of serum creatinine, and death.

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Alterations in arterial blood pressure and plasma osmolality are the main physiologic signals regulating ADH secretion. However, you may find that 100mg takes longer to start working if you take it with a heavy meal.

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